Abstract:The valuable elements that can be comprehensively recycled from a polymetallic ore in Gansu province are copper, gold, silver and sulfur. According to the characteristics of high secondary copper content, close copper-sulfur intercalation and fine particle size of useful minerals, the experimental research adopts the process flow of “copper-sulfur mixed flotation-coarse concentrate regrinding –copper-sulfur separation” and the new reagent ester -11 ,which obtains not only the copper concentrate with copper grade of 19.05%, copper recovery rate of 90.07%, gold grade of 7.46g/t, gold recovery rate of 60.43%, silver grade of 42.00g/t, silver recovery rate of 41.20% ,but also the sulfur concentrate with sulfur grade of 41.28% and sulfur recovery rate of 62.22%. It provides technical basis for comprehensive recovery of the ore.