Abstract:The valuable minerals of a high molybdenum and low lead ore in Tibet are molybdenite and galena, molybdenum ore has great disparity in grain size, which is associated with or wrapped by minerals such as quartz, pyrite, galena, etc., the embedding relationship is complicated. Galena has fine grain size, which is mostly produced in quartz. The conventional "molybdenum-lead full-mixed flotation and re-separation" process is adopted in industrial production, which has the disadvantage such as high mutual content of molybdenum concentrate and lead concentrate , low metal recovery rate and low molybdenum concentrate grade.. According to the ore characteristics, the process of "preferentially selecting some high-quality molybdenum concentrates-molybdenum-lead mixed flotation-mixed coarse concentrate regrinding- separating molybdenum lead separation" and the new type of collecting foaming agent ester -22 with strong collecting ability for molybdenum minerals were adopted. High-quality molybdenum concentrate 1 with a molybdenum grade of 49.82% and molybdenum concentrate 2 with a molybdenum grade of 45.65% were obtained, respectively. that total recovery rate of molybdenum in the two molybdenum concentrates was 90.91%, and the lead concentrate with a lead grade of 46.08% and a lead recovery rate of 82.58%, compared with the "total mixed flotation and re-separation" process, not only the mutual content of molybdenum concentrate and lead concentrate is low, but also the high-quality molybdenum concentrate with a molybdenum grade of 49.82% can be obtained, and the economic benefit is remarkable.The experimental conclusion provide a basis for the production technical transformation, besides, it provides a technical reference for the recovery of the same type of ore.