Abstract:In the acid system, the dissolution of alkaline gangue minerals is obviously affected by the grinding fineness and acid dosage. The mineral dissolution changes the system pH, increases the soluble ions, and affects the flotation of sulfide minerals. In order to explore the influencing factors and their interaction in the process of Carlin type gold ore flotation sulfide ore under acidic system, response surface optimization experiment was conducted on the basis of single factor experiment, and the interaction of grinding fineness, H2SO4 dosage and butyl xanthate dosage on flotation was analyzed. The results show that the influence of three factors on the recovery rate of sulfur concentrate is: grinding fineness>butyl xanthate dosage>H2SO4 dosage; The influence on sulfur concentrate grade is as follows: butyl xanthate dosage>grinding fineness>H2SO4 dosage. Grinding fineness has a great influence on flotation indexes, which is a significant factor; The interaction between grinding fineness and the amount of collector has a significant effect on flotation indexes.