Abstract:The primary reasons for mineral interaction effects in complex ores are the fine dissemination of valuable minerals and the abundance of associated minerals，so the ores have to be finely ground to achieve individual liberation of the minerals. This results in a product with particles of varying sizes and compositions，which affect the flotation separation between minerals due to the interaction effects of physical and chemical factors. Against this backdrop，definition of mineral flotation interaction effects is put forward，namely the influence on flotation separation exerted by mutual adsorption，activation，inhibition，surface transformation，and other such phenomena between two or more minerals within a mineral flotation system. The forms of these interaction effects are further introduced，namely direct and indirect interaction effects，and providing a comprehensive overview of the effects of coarse versus fine mineral interaction effects，fine mineral interplay，and indirect interactions on flotation，as well as discussing the current understanding of the underlying mechanisms governing these mineral interaction effects. The ultimate aim is to lay the groundwork for developing strategies to either exploit or mitigate mineral interaction efffects in flotation processes.